Mimotopes are peptides that mimic the effects of specific B-cell epitopes in stimulating an immune response. Immunization with such mimotopes would be expected to induce an immune response directed at the target disease related antigen. As such they have great utility as potential immunotherapeutic approaches for various cancers in much the same way as HER-Vaxx is being used to stimulate an immune response to the tumour antigen HER2 in breast or gastric cancer.
Using a proprietary screening platform, it has been possible to screen libraries of peptides using antibodies for candidates that mimic the effect of target epitopes. Imugene has acquired an option to continue this research and development of Mimotope Vaccines with the Company’s scientific team in Austria.